Collagen VI encodes antimicrobial activity: novel innate host defense properties of the extracellular matrix.
نویسندگان
چکیده
Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate Immun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense.
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عنوان ژورنال:
- Journal of innate immunity
دوره 4 4 شماره
صفحات -
تاریخ انتشار 2012